NOS3 and hepatocellular carcinoma: With respect to the freely moving mice, the studies found that (1) the ventilatory responses to HXC were enhanced in nNOS–/– mice compared to WT mice70,111, (2) the ventilatory responses to HXC were reduced in eNOS–/– mice70, (3) the ventilatory responses during HCC in nNOS–/– and eNOS–/– mice were similar to those in WT mice70,111,112, and (4) short-term potentiation of ventilatory parameters after HXC was virtually absent in nNOS–/– mice84,85 with no report if eNOS–/– mice were studied.