No significant changes were observed for the expression of ACSL1, DGAT1 or ACDVL. Because obesity is related to chronic low grade inflammation, we also analysed PBMC mRNA expression of the proinflammatory genes IL6 and TNF-alpha, which was not different between the NW and OW-OB groups. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.