Total CD11b+ F4/80+ macrophages were significantly higher in CtD infected C57BL/6, TNFR1/2−/−, and P2X7R−/− mice compared to mock infection but did not differ among the infected mice (Fig. 6g), excluding the possibility that GT pathology observed in TNFR1/2−/− and P2X7R−/− mice (Fig. 6f) were not due to differences in macrophages recruitment. This evidence concerns the gene ITGAM and infection.