Two experimental findings in Fig. 1 provided insight about possible CT135 function: (i) CtD infections produced significantly high burdens early pi implying an important pathogenic function of CT135 in the avoidance of early innate immune factors, and (ii) CtD infection, but not CtD CT135−/− caused macrophage-associated pathology implicating a role for CT135 in immunopathogenesis. Here, CIMAP1A is linked to infection.