CtD infected NLRP3−/−, Casp1/11−/−, IL-1β−/−IL-18−/−, and IL-1R−/− mice all exhibited significantly greater infectious loads at day 3 and 7 pi showing NLRP3/Caspase1 inflammasome signaling pathway is critical for controlling early chlamydial infection (Fig. 5g–k). Here, IL1B is linked to chlamydia trachomatis infectious disease.