BIN1 and Alzheimer disease: In the leave-one-out analysis and the single SNP analysis, rs4663105 (near BIN1 gene) was driving the main effect in the causal estimate for AD on the precentral and the results of the isthmus cingulate were not influenced by a single genetic variant (see Supplementary Tables 15 and 16, Additional File 1 and Supplementary Figs. 17–20, Additional File 2).