The leave-one-out analysis and the single SNP analysis showed that rs442495 (near ADAM10 gene) played an important role in the causal estimate for AD on the cuneus and no influential single genetic variant was found in the results of the lateral occipital and lingual (see Supplementary Tables 19 and 20, Additional File 1 and Supplementary Figs. 31–36, Additional File 2). This evidence concerns the gene ADAM10 and Alzheimer disease.