However, rs11257238 (near ECHDC3 gene) and rs4575098 (near ADAMTS4 gene) were driving the main effect in the causal estimate for AD on the cuneus and pericalcarine respectively (see Supplementary Tables 15 and 16, Additional File 1 and Supplementary Figs. 23–26, Additional File 2). This evidence concerns the gene ECHDC3 and Alzheimer disease.