Moreover, an FPR1/FPR2 dual agonist, compound 17b, preserves cardiac function in models of acute myocardial infarction (42), while another dual agonist, compound 43, affords cardio protection in experimental heart failure induced by permanent coronary artery ligation through its ability to modify macrophage phenotype (43). This evidence concerns the gene FPR2 and myocardial infarction.