Additionally, when compared with vehicle, hrAnxA1 significantly decreased collagen deposition (Fig. 7E) and the number of galectin-3–positive cells (Fig. 7F) in K/BxN F1 hearts indicative of a negative impact on disease evolution to more advanced cardiac remodeling, including cardiac hypertrophy and fibrosis. This evidence concerns the gene LGALS3 and cardiac hypertrophy.