When these models were adjusted for LATE-NC, all models had nominally significant adjusted meta-analytic associations with HS with the exception of the APOE SNV (rs769449) and APOE ε4 carrier status (Table 5, Fig. 8), suggesting that the association between APOE status and HS is related to a more direct interaction between APOE and LATE-NC (i.e., TDP-43 proteinopathy). The gene discussed is APOE; the disease is proteostasis deficiencies.