ALB and atherosclerosis: In the present study, we observed that patients in higher quartile of serum albumin had lower VPT values, an useful and reliable method for early screening DPN and reflecting the clinical severity [19], and prevalence of DPN, and serum albumin showed a negatively association with VPT values and prevalence of DPN, demonstrating the potential neuroprotective effects of serum albumin on the development of DPN possibly due to its antioxidant, anti-inflammatory, and anti-atherosclerosis.