After further treatment, the AS events of TSEN54, MYB, SERF1B, ZNF630 and AGO2 were most closely associated with the prognosis of OC, and they were all good prognostic factors.tRNA splicing endonuclease(TSEN) catalyz tRNA intron removal in eukaryotes,and TSEN54 is a TSEN is one of the core subunits.The gene mutation of TSEN54 mostly leads to nervous system lesions, most studied cause of pontocerebellar hypoplasia.There has been a lack of research on the relationship between OC [30–32]. Here, SERF1B is linked to pontocerebellar hypoplasia.