GAL3ST1 and Alzheimer disease: Immunostaining of GFAP or Iba1 on cerebrum revealed a dramatic upregulation of GFAP and Iba1 in brain regions where sulfatide is present/enriched, including CC and AD relevant brain regions, e.g., the inner cortical layers and partial hippocampus substructure in both CST cKO (Fig. 5B, C) and CST KO mice (Fig. S7A,B).