GAL3ST1 and Alzheimer disease: To investigate the consequences and related molecular mechanisms of adult-onset sulfatide deficiency, a specific event that occurs very early in AD, on brain homeostasis and cognitive function, we generated a novel mouse model by inducible and conditional depletion of the cerebroside sulfotransferase (CST, a.k.a. Gal3st1) gene, which codes for the enzyme that catalyzes the last step of sulfatide biosynthesis, within myelinating cells.