The CTCL mutation frequency was relatively high, reaching 6.3%, and no TNFAIP3 mutations were found in anaplastic large cell lymphoma (ALCL), NKTCL, hepatosplenic T-cell lymphoma (HSTCL), or large granular T lymphocyte leukemia (T-LGLL) (Fig. 2A). This evidence concerns the gene TSPYL2 and hepatosplenic T-cell lymphoma.