Recently, PF4 also has been associated with vector-based SARS-CoV-2 vaccine-induced thrombosis with thrombocytopenia syndrome (VITT/TTS), thus, emphasizing the clinical significance of PF4 in PF4/polyanion complex formation, and the occurrence of VITT/TTS [57–62]. The gene discussed is PF4; the disease is Venous thrombosis.