IDH2 and central nervous system cancer: The larger database made by the Cancer Genome Atlas (TCGA) Research Network showed 2 KRAS mutation and 2 NRAS mutation in 590 glioblastomas, and 1 KRAS mutation and 1 NRAS mutation in low grade gliomas with IDH-mutant and 1p/19q codeletion, and 1 KRAS mutation and 2 NRAS mutation in those with IDH-mutant and no 1p/19q codeletion [52].