Additionally, a number of VGKCs including KCNB2, KCNF1, KCNK6, KCNK9 and KCNJ5 are significantly upregulated in the NRXN1α+/- transcriptome, and gain of function of VGKCs has been identified in neurodevelopmental disorders including epilepsy [48–50]. This evidence concerns the gene KCNJ5 and neurodevelopmental disorder.