Subsequently, with HE staining and flow cytometry sessions, we observed that the damages of tumor tissue morphology and the content of CD4 + and CD8 + cells were the smallest in the sh-control + IgG control group, while the two indicators increased following the order of the sh-control + anti-PD-L1 group, the sh-eIF5B + IgG control group, and the sh-eIF5B + anti-PD-L1 group (P < 0.01, Fig. 5D and E). Here, CD8A is linked to neoplasm.