EGFR and autism: Given that key components of conserved signaling pathways like Notch, Hedgehog, Wnt, and epidermal growth factor receptor (EGFR) were identified using Drosophila wings models [85–91], Drosophila wing provides an effective system to evaluate the role of autism and other neurodevelopment-related genes in identifying a signaling pathway that could be affected during development [92].