APP and early-onset autosomal dominant Alzheimer disease: They created a knock-in mouse for Cre recombinase–dependent expression of human APP carrying the familial Alzheimer disease Swedish (KM670/671NL) and Indiana (V717F) mutations and bred it with a previously established liver cell–specific Alb-Cre mouse line [7] to make hepatocyte-specific human amyloid (HSHA) mice.