Knocking out NSP5 abolishes formation of these structures even when other viral proteins are present during infection (Papa et al, 2020a; Fig EV1), while NSP5 co‐expression with RV multivalent RNA‐binding proteins, e.g. NSP2 (Berois et al, 2003; Eichwald et al, 2004), results in formation of such condensates. Here, SPECC1 is linked to infection.