Among them, KLF6, a target gene related to GCC, was chosen for further study (Fig. 3B), since KLF6 functions as an important regulator controlling the occurrence and development of various tumors, including thyroid cancer, ovarian cancer and gastric cancer (Yang et al. 2019; Han et al. 2020; Li et al. 2020). Here, KLF6 is linked to goblet cell carcinoma.