KLF6 and goblet cell carcinoma: In conclusion, the expression of miR-200c-3p in clinical GCC tissues and cell lines was significantly higher, and miR-200c-3p negatively regulated the expression of KLF6 by acting on the 3’-UTR region of KLF6, thus inhibiting the growth and metastasis of GCC cells, which will provide research basis for gene targeted therapy of GCC in the future.