Among them, KLF6, a target gene related to GCC, was chosen for further study (Fig. 3B), since KLF6 functions as an important regulator controlling the occurrence and development of various tumors, including thyroid cancer, ovarian cancer and gastric cancer (Yang et al. 2019; Han et al. 2020; Li et al. 2020). This evidence concerns the gene KLF6 and ovarian carcinoma.