1979) and are the result of misfolding of cytoskeletal proteins and proteasome overload. MB on routine LM show a very irregular, eosinophilic mass in an empty space in the parenchymal cell. Unfortunately, EM descriptions of MB in situ are very rare. MBs are often observed in livers showing ballooning and fibrosis. MB do not possess a limiting membrane and contain not only filamentous structures but also material difficult to describe (Denk et al. 1979; Franke et al. 1979; Zatloukal et al. 2007). This evidence concerns the gene DNM2 and Mobius syndrome.