LCN2 and kidney disorder: Nevertheless, Mut−/−;TgINS−Alb−Mut mice displayed chronic tubulointerstitial nephritis, had ultrastructural changes in the proximal tubule mitochondria, increased expression of Lcn2 [126] and severe kidney disease [147] while Mmut−/−;TgINS−MCK−Mut mice showed growth retardation, and liver and kidney mitochondriopathy [129].