Several studies demonstrated the role of this biomarker in noninvasive assessment of MF and the usefulness for prognosis of cardiovascular diseases such as heart failure, dilated and hypertrophic cardiomyopathy.11,23 In AS pressure overload induces MF that leads to increased chamber stiffness, diastolic dysfunction, and significant expression of NT-proBNP levels.24, –26 Our study revealed the moderate correlation between larger diffuse MF extent and higher concentrations of this biomarker (r = 0.47, p = 0.005). The gene discussed is NPPB; the disease is heart failure.