However, studies have shown that T2D patients treated with basal insulin only or antihyperglycemic medications (e.g., sulphonylureas) are at increased risk for frequent and/or severe hypoglycemia, particularly older patients.11–13 In addition to the clinical consequences of severe hypoglycemia, these episodes have been shown to diminish patient's willingness to adhere to their prescribed treatment regimens, which can lead to deterioration of glycemic control and increased risk of long-term complications.14,15. Here, INS is linked to Hypoglycemia.