The extent of improvement in GMI observed in this study contrasts with the ∼20% of adults who achieved an HbA1c of <7% in the United Kingdom National Diabetes Audit9 and in the United States T1D Exchange,20 and 26.2% and 27.0% of participants in the western Europe and eastern Europe regions, respectively, of the SAGE study.8 Recent clinical studies addressing treatment with the automated insulin delivery system in the adolescent and young adult population have shown varied findings. The gene discussed is INS; the disease is diabetes mellitus.