FN1 and juvenile polyposis syndrome: While Staphylococcus aureus employs a plethora of surface-bound (microbial surface components recognizing adhesive matrix molecules [MSCRAMMs]; clumping factors, collagen adhesins, fibronectin and fibrinogen-binding proteins, elastin-binding, host cell adhesions) and secreted virulence factors (leukocidins, hyaluronidases, lipases, etc.)to combat such hazards, the role of rapid bacterial aggregation within the joint is under investigation as an early protective step in the mechanism of establishing chronic PJI (12, –, 15).