In IgG+ cMBCs, IgM+ atMBCs, and IgG+ atMBCs, several IGHV genes showed differential usage between malaria-naive and malaria-experienced individuals (Fig. 5; Fig. S7 at https://doi.org/10.6084/m9.figshare.16449858.v3). This evidence concerns the gene CD40LG and malaria.