In subsequent studies, it was found that the Ca2+/CaN/NFAT signalling pathway plays a more significant role in the regulation of cell growth and development, such as regulating cardiomyocyte differentiation, chondrocyte differentiation, myocyte hypertrophy, angiogenesis, myogenesis, skeletal development and regeneration, etc.8, 9, 10, 11, 12, 13, 14, 15Studies have shown that the (Down syndrome critical region 1) DSCR1 gene on chromosome 21 of patients with Down syndrome is overexpressed. This evidence concerns the gene RCAN1 and Down syndrome.