Depletion and mutations of Rbm20 in rodent and pig models have also shown severe DCM and arrhythmias (Guo et al., 2012; van den Hoogenhof et al., 2018; Ihara et al., 2020; Khan et al., 2016; Schneider et al., 2020). Here, RBM20 is linked to cardiac arrhythmia.