To investigate further, we measured markers of cardiac injury by quantitative reverse transcriptase PCR and the data show that expression of known heart failure and fibrosis markers BNP (Nppb), periostin (postn), and Collagen 1A (Col1A) mRNA are all elevated in the right ventricles of the transgenic mice compared to control (Figure 3a). The gene discussed is POSTN; the disease is heart failure.