TNF and neoplasm: In tumor microenvironment, the phagocytosis of the debris produced by necrotic cells stimulates macrophages to release a large amount of TNF‐α, which in turn recruit other inflammatory cells from the immune system.[17] However, these inflammatory cells could go awry and stimulate tumor development by promoting angiogenesis, proliferation and invasion of cancer cells.[18, 19] Thus, it is crucial to avoid tumor necrosis during cancer therapy.