ADCY3 and obesity due to melanocortin 4 receptor deficiency: The matching of EWAS targets with a large GWAS meta-analysis of body mass index (BMI) in humans led to the identification of overlapping genes included TFAP2B, which influences the effect of dietary fat on weight [53], GPR61, which is involved in the regulation of food intake and body weight [54, 55], and ADCY3 and SKOR1, both of which are associated with obesity and BMI [56–59].