Moreover, macrophage infiltration in WAT and mRNA levels of the inflammation markers MCP1, F4/80, and TNFα were found to be diminished in two mouse models of partial leptin deficiency (OBHZ and LepHZ mice), after a chronic high-fat (HF) diet feeding, suggesting that lower leptin levels within an obesogenic environment may be beneficial for obesity and insulin development prevention [140]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.