When we restricted analysis to Japanese bilateral non-syndromic hearing loss patients, the prevalence of TMC1-associated hearing loss was 0.17% (20/11,594) for all patients, 0.61% (15/2462) for ADNSHL and 0.07% (5/6912) for ARNSHL or sporadic hearing loss cases. The gene discussed is TMC1; the disease is hearing loss disorder.