The main findings of this study are as follows: (a) While the rate of incidence of late adverse events after X‐EES implantation was low, it continued to increase gradually over time up to 10 years after stent implantation; and (b) insulin‐treated diabetes, left ventricular dysfunction (LVEF <35%), hemodialysis, peripheral vascular disease, and in‐stent restenosis were independent risk factors of clinically indicated TLF. This evidence concerns the gene INS and peripheral vascular disease.