In another study involving a diet-induced mouse model of liver fibrosis, supplementation of nicotinamide riboside (NR), a NAD precursor, attenuated hepatic stellate cell activation resulting in decreased liver fibrosis [22]. Moreover, in vitro study involving palmitate-incubated Hep G2 cells, primary human liver cells, and niacin showed inhibition of lipid deposition, decreased NADPH oxidase activity, low IL-8 cytokine level, and reduced ROS production [18]. The gene discussed is CXCL8; the disease is Hepatic fibrosis.