Menzies and colleagues similarly showed that expanding TB diagnostics and care access produced substantial health gains to achieve the goals set out in the End TB strategy, based on an analysis of nine cost-effectiveness models in China, India and South Africa.24 We posit that these gains and cost savings can only be maximised if the AHD package is fully implemented with everyone who should receive CD4, CrAg and TB-LAM testing, with the appropriate therapy for those diagnosed with disease. The gene discussed is CD4; the disease is tuberculosis.