LEP and obesity due to melanocortin 4 receptor deficiency: Understanding the role of the pathophysiologic factors, leptin, the SNS, the RAAS and the NP in the pathogenesis of obesity-related HT, is key for successful treatment option development for HT in obese individuals as evidenced by other studies (Chrysant 2019; Landi et al. 2018; Roka et al. 2015), and future studies should examine these factors in this community.