The combination of EGFR-targeted therapies with cytotoxic agents is also extensively investigated, mostly with gemcitabine, both agents in combination with tyrosine kinase inhibitors (NCT00075686, NCT00040183), or the use of antibody-drug conjugates to achieve selective and specific delivery of cytotoxic agents to the tumor cells 4,20. This evidence concerns the gene EGFR and neoplasm.