Our findings from the 3-wk TG model is in keeping with published studies, showing that inducible gene knockout of YAP or TEAD1 leads to onset of DCM within a few weeks 12, 15, 16, 18, and that TEAD1-KO results in profound mitochondrial dysfunction 16, 17. This evidence concerns the gene TEAD1 and familial dilated cardiomyopathy.