Using cardiomyocyte-restricted TEAD1-deletion (TEAD1-cKO) models, two independent groups have recently reported rapid onset of DCM phenotype, together with downregulation of mitochondrial genes and mitochondrial dysfunction 16-18, implying a role of TEAD1 in mitochondrial integrity and function 16-18. Here, TEAD1 is linked to familial dilated cardiomyopathy.