In this regard, the TSPO ligand 18F-GE-180 is proven effective for robust imaging of microglial activation in a mouse model of amyloidosis, and shows the normalization of TSPO binding upon treatment with a neurotrophin receptor ligand that ameliorates hyperphosphorylation and misfolding of tau, and rescues the consequent neurite degeneration 9. Here, TSPO is linked to amyloidosis.