Recently, Wang et al. indicated that simvastatin inhibits the proliferation, migration, and invasion of the NSCLC cell lines H1299 and A549 by inducing pyroptosis, which was accompanied by elevated levels of NLRP3 and cleaved caspase-1 and the maturation of IL-1β and IL-18. The gene discussed is CASP1; the disease is non-small cell lung carcinoma.