GSDME and hepatocellular carcinoma: Zhang et al. suggested that miltirone inhibits the phosphorylation of MEK and ERK1/2 and leads to the intracellular accumulation of ROS, which facilitates BAX-mediated caspase-3 activation and GSDME-induced pyroptosis in the mouse HCC cell line Hepa1-6 and in C57BL/6 male mice inoculated with Hepa1-6 cells 200.