Ma demonstrated that the silencing of RP1‐85F18.6 by siRNA could result in increased GSDMD-N and pyroptosis in the colon adenocarcinoma cell line SW620, and this effect inhibits cancer cell proliferation, invasion and metastasis; hence, GSDMD is considered a favorable biomarker for patients with CRC 165. This evidence concerns the gene GSDMD and colorectal carcinoma.