PTPRC and colorectal carcinoma: Interestingly, CD45 knockdown also attenuated CRC growth under serum-limited conditions (0.1% FBS) and ultralow attachment conditions, all of which are known to induce cellular stress and death in epithelial cells 16-21 (Figures S3M-O), suggesting that high CD45 expression enhanced CRC cell growth under stressful conditions, such as therapy treatment, serum deprivation, and ultralow attachment conditions.