However, its clinical significance in patients with CRC has been ambiguous; the increased infiltration of CD45+ immune cells within primary tumors was reported to be associated with a better survival rate in patients with CRC 28, while the comparison of gene expression profiles between metastatic tumors and primary tumors suggested an association between increased CD45 expression and CRC metastasis 29. The gene discussed is PTPRC; the disease is metastatic neoplasm.