These nanoplatforms had high relaxivity values (60 mM-1 s-1 per Gd at 1 T), which, coupled with the dual targeting strategies employed in the NPs (targeting of ανβ3 integrins through RGD peptide and targeting of tumour microenvironment via addition of an MMP-2 substrate), resulted in the highest uptake of T-MAN in gastric tumours 12 h post injection (~23.4% ID% g-1) and translated in a significant T1 signal enhancement. Here, MMP2 is linked to gastric neoplasm.