Although there is a KDM5C homolog KDM5D in the Y chromosome, it is worth noting that male ccRCCs with a KDM5C loss-of-function mutation were more likely to lose Y chromosome than those without such a mutation 14, indicating the necessity of KDM5C deficiency in ccRCC development. Here, KDM5C is linked to nonpapillary renal cell carcinoma.