Several large-scale clinical genomic profiling has shown the presence of a large number of chromatin modifier genes in ccRCCs, including PBRM1, SETD2, BAP1, KDM5C, and MLL225, 26, but none of them is associated with the characteristic metabolic phenotypes of ccRCC. This evidence concerns the gene KDM5C and nonpapillary renal cell carcinoma.