Interestingly, Cxcl13 that is involved in inflammatory response in CNS diseases including multiple sclerosis and progressive myoclonus epilepsy of Unverricht-Lundborg type 70-72 was strongly up-regulated by SCI (FC = +50.21) and decreased by GW2580 treatment (FC = -3.34), suggesting that GW2580 may inhibit neuroinflammation through CXCL13-mediated signaling pathway in SCI. The gene discussed is CXCL13; the disease is multiple sclerosis.