Our previous studies demonstrated that angiotensin-(1-7) [Ang-(1-7)], which is cleaved from Ang II by angiotensin-converting enzyme 2 (ACE2), counteracts the deleterious effects of the ACE-Ang II-Ang II type 1 receptor (AT1R) axis, and thus, the ACE2-Ang-(1-7)-Mas receptor (MasR) axis has been recognized as a promising approach to the treatment of cardiovascular diseases including diabetic cardiomyopathy 8-10. The gene discussed is ANG; the disease is diabetic cardiomyopathy.