AGT and diabetic cardiomyopathy: One major finding of the present study was that Ang IV treatment dose-dependently attenuated diabetic cardiomyopathy via down-regulating FoxO1-mediated autophagy, which was supported by our in vitro result that Ang IV promoted FoxO1 phosphorylation and suppressed FoxO1 nuclear translocation induced by HG in cardiomyocytes.