AFP and neoplasm: Cox's multivariate proportional hazards model identified some risk factors for overall survival (Table 2): AFP ≥ 20 ng/mL (hazard ratio (HR): 2.121, 95% confidence interval (CI): 1.364-3.032, P = 0.008); tumor size ≥ 5 cm (HR: 2.998, 95% CI: 1.841-3.798, P = 0.001); microvascular invasion (HR: 2.125, 95% CI: 1.451-2.945, P < 0.001); and high PRMT4 expression (HR: 1.985, 95% CI: 1.451-3.754, P = 0.003).