MKI67 and breast cancer: A previous study indicated that PRMT4 is associated with the histological type of breast cancer and is less frequently expressed in lobular and tubular types, and a positive correlation was found between PRMT4 expression and biomarkers associated with a nonluminal phenotype and poor prognosis, such as HER-2, basal cytokeratins, and the proliferation marker Ki67 18.