MiR-139-5p was confirmed to negatively regulate ZEB1 and ZEB2 expression 31, which induces EMT and promotes the progression of malignant carcinoma 54, while overexpression of ZEB1 and ZEB2 abolishes the inhibitory effects of miR-139-5p on HCC cell migration and invasion 31. This evidence concerns the gene ZEB2 and hepatocellular carcinoma.