Therefore, we suggested that TP-5 alleviated the pathological aging of ovary by reducing the inflammatory factors.According to some reports, TP-5 effectively regulates immune cell activity and homeostasis and the release of immune factors; however, there are no reports on its efficacy in the treatment of POF, and it is unclear whether it can alleviate the symptoms of POF by targeting the regulation of T cells and Mø. The gene discussed is TMPO; the disease is premature menopause.