DNMT1 and colorectal carcinoma: To further test if DNMT1 was indeed involved in regulating STAT1 expression, we ectopically overexpressed DNMT1 in alisertib-resistant CRC cells and found that the levels of p-STAT1 and total amount of STAT1 were dramatically suppressed in DNMT1 expressing CRC cells, compared with that of control vector expressing CRC cells (Figures S5C and S5D).