MAPT and mucopolysaccharidosis type 3A: Indeed, a recent study in a mouse model of Sanfilippo syndrome type A showed massive lysosomal storage of amyloidogenic proteins including α-synuclein, Aβ, tau, and PrP in the brain, leading to mislocalization of the lysosomes in the neuronal perikarya and preventing their fusion with autophagosomes, which concentrated in the cell periphery and axons26.